Using The BC Linked Health Database to Understand Whether Depression Changes the Course of Heart Disease in AMI Patients

Project number: 
Approval date: 
Monday, January 1, 1900
Principal Investigator: 
Grunau,Gilat Linn
Not Available
Funding Agency: 
Not Available
Datasets requested: 
Consolidation registry (Ministry of Health)
Medical Services Plan (BC Ministry of Health)
PharmaCare (BC Ministry of Health)
Deaths (BC Vital Statistics Agency)
Research objective: 

Depression following myocardial infarction is common and there is equivocal evidence that it may increase the risk for mortality, morbidity and health services utilization, at least in the short term. Moreover, antidepressant use in patients who have had an AMI could result in increase cardiovascular risk due to the medication side effects. This study will investigate whether depression after MI poses a long-term risk for these patients and will explore the impact of antidepressant use. the results will contribute to the body of knowledge about the impact and treatment of depression after AMI, and the utility of administrative databases to investigate these questions.


Journal Publication

  • Grunau, G. L.; Ratner, P. A.; Goldner, E. M.; Sheps, S. "Is early- and late-onset depression after acute myocardial infarction associated with long-term survival in older adults? A population-based study." The Canadian Journal of Cardiology  (2006) 22 6  473-478
  • Grunau, G. L.; Sheps, S.; Goldner, E. M.; Ratner, P. A. "Specific comorbidity risk adjustment was a better predictor of 5-year acute myocardial infarction mortality than general methods." Journal of Clinical Epidemiology (2006) 59 3  274-280

Academic thesis or dissertation

  • Grunau, Gilat Linn "Predicting outcomes of acute myocardial infarction using administrative data : is depression associated with survival?" 2006

Page last revised: December 5, 2017