Role of statins in prevention and management of rheumatoid arthritis

Project number: 
07-017
Approval date: 
Friday, March 27, 2009
Principal Investigator: 
Choi,Hyon
Institution: 
Arthritis Research Centre of Canada
Funding Agency: 
Canadian Institutes of Health Research(CIHR)
Datasets requested: 
Hospital Separations (BC Ministry of Health)
consolidation - census geocodes
PharmaCare (BC Ministry of Health)
Consolidation file (BC Ministry of Health)
PharmaNet
Home and Community Care (BC Ministry of Health)
Medical Services Plan (BC Ministry of Health)
Deaths (BC Vital Statistics Agency)
bc cancer
Research objective: 

The goals of this project are to study the potential role of statin therapy in the prevention and management of rheumatoid arthritis (RA) and to evaluate the clinical utility and cost-effectiveness of these drugs. Statins have been shown to reduce the risk of cardiovascular morbidity and mortality with recent data indicating that statins not only improve lipid levels but also have antiinflammatory effects. yet, no population data are available on the role of research are: 1) to determine whether statins reduce the risk of developing RA among the general population, using individuals with hyperlipidemia and non-statin users as control groups; and 2) to determine whether statins reduce the risk of coronary artery disease (CAD) and death among RA patients using those RA patients who are non-statin users as a control group; and 3) to calculate the cost-effectiveness of statin therapy in RA

Publications: 

Journal Publication

  • De Vera MA, Choi H, Kopec J, Goycochea-Robles MV, Lacaille D. Statin discontinuation and risk of acute myocardial infarction in patients with rheumatoid arthritis: a population-based study. Annals of the Rheumatic Diseases, Jun 2011. 70(6). PubMed ID: 21378405

Page last revised: December 5, 2017