A Population-based analysis of the effectiveness and adverse effects of medications in patients with atrial fibrillation

Project number: 
08-001
Approval date: 
Tuesday, January 27, 2009
Principal Investigator: 
Humphries,Karin
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Canadian Institutes of Health Research(CIHR)
Datasets requested: 
Hospital Separations (BC Ministry of Health)
Consolidation - demographic (Ministry of Health)
Deaths (BC Vital Statistics Agency)
consolidation - census geocodes
PharmaNet
Consolidation file (BC Ministry of Health)
Medical Services Plan (BC Ministry of Health)
Consolidation registry (Ministry of Health)
Research objective: 

Conduct a population-based analysis of administrative databases in order to evaluate the use of cardiac medications and outcomes in patients with atrial fibrillation (AF) in Quebec, Ontario, and British Columbia (BC). The objective is to develop a program of population-based research on medication use in AF patients. Specifically, we aim to describe at the population level, the effectiveness, adverse effects, and sex-based differences associated with AF medications.

Publications: 

Journal Publication

  • Shah M, Avgil Tsadok M,  Jackevicius CA, Essebag V, Eisenberg MJ, Rahme E, Humphries KH, Tu JV, Behlouli H, Pilote L "Warfarin Use and the Risk for Stroke and Bleeding in Patients with Atrial Fibrillation Undergoing Dialysis." Circulation 2013
  • Tsadok MA, Jackevicius CA, Rahme E, Humphries KH, Behlouli H, Pilote L. Sex Differences in Stroke Risk among Older Patients with Recently Diagnosed Atrial Fibrillation. JAMA. 2012 May 9;307(18):1952-8.
  • Tsadok MA, Jackevicius CA, Essebag V, Eisenberg MJ, Rahme E, Humphries KH, Tu JV, Behlouli H, Pilote L. Rhythm versus rate control therapy and subsequent stroke or transient ischemic attack in patients with atrial fibrillation. Circulation. 2012;126(23):2680-7.

Page last revised: December 5, 2017