The Epidemiology and Impact of Comorbidity on MS in Canada (ECoMS) - Characterization of Comorbidities in MS

Project number: 
10-007
Approval date: 
Friday, March 9, 2012
Principal Investigator: 
Tremlett,Helen
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Canadian Institutes of Health Research(CIHR)
Datasets requested: 
MSP Registration & Premium Billing(BC Ministry of Health)
consolidation - census geocodes
Medical Services Plan (BC Ministry of Health)
PharmaNet
Hospital Separations (BC Ministry of Health)
Consolidation - demographic (Ministry of Health)
Deaths (BC Vital Statistics Agency)
Consolidation registry (Ministry of Health)
Research objective: 

The aim of this project is to identify comorbidities among patients with MS, how these vary across sociodemographic groups, and differ from comorbidities in the general population.

-to identify comorbidities among patients with MS occurring with a frequency >=5%
-to determine which comorbidities occur with different frequencies than in the general population
-to determine temporal trends in MS-related comorbidities
-to describe the burden of illness related to MS in British Columbia; specifically, to estimate annual incidence and prevalence and trends in MS among British Columbia residents with stratification by age, sex, and geographic region of residence.
-to determine how comorbidity affects health-related quality of life (HRQoL) in MS
-to determine how psychiatric symptoms which do not meet formal diagnostic criteria affect HRQoL in MS

Publications: 

Journal Publication

  • Zhang T, Tremlett H, Tennakoon A, Leung S, Zhu F, Kingwell et al. Examining the effects of comorbidities on disease-modifying therapy use in multiple sclerosis. Neurology. 2016;86:1-9.
  • Marrie, Ruth Ann, et al. "Chronic lung disease and multiple sclerosis: Incidence, prevalence, and temporal trends." Multiple Sclerosis and Related Disorders 8 (2016): 86-92.
  • E. Kingwell, F. Zhu, R.A. Marrie, J.D. Fisk, C. Wolfson, S. Warren, J. Profetto-McGrath, L.W. Svenson, N. Jette, V. Bhan, B.N. Yu, L. Elliott, H. Tremlett. High incidence and increasing prevalence of multiple sclerosis in British Columbia, Canada: findings from over two decades (1991-2010). J Neurol. 2015 DOI: 0.1007/s00415-015-7842-0
  • Kingwell, Elaine, et al. "High incidence and increasing prevalence of multiple sclerosis in British Columbia, Canada: findings from over two decades (1991–2010)." Journal of neurology 262.10 (2015): 2352-2363.
  • Marrie, Ruth Ann, et al. "Differences in the burden of psychiatric comorbidity in MS vs the general population." Neurology 85.22 (2015): 1972-1979.

Conference abstract/presentation

  • McKay KA, Tremlett H, Zhu F, Kastrukoff L, Marrie RA, & Kingwell E. (2016). A population based study comparing multiple sclerosis clinic users and non-users in British Columbia, Canada. European Journal of Neurology, 23(6), 1093-1100
  • Kingwell, Elaine, et al. “High incidence and increasing prevalence of multiple sclerosis in British Columbia, Canada: findings from over two decades (1991-2010).” 2014 Joint ACTRIMS-ECTRIMS Meeting, 10th-13th September in Boston.

Page last revised: December 5, 2017