The population trend in fertility drug use and its impact on pregnancy outcomes

Project number: 
10-C04
Approval date: 
Friday, October 14, 2011
Principal Investigator: 
Lisonkova,Sarka
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Michael Smith Foundation (MSFHR)
Datasets requested: 
Perinatal Services BC
Deaths (BC Vital Statistics Agency)
PharmaNet
Stillbirths (BC Vital Statistics Agency)
Births (BC Vital Statistics Agency)
Research objective: 

1) To compare the rates of multi-fetal births between women who conceived using clomiphene and those who conceived without such drug use (during the years 2000-2008.

2) To compare rates of adverse birth outcomes (including preterm birth, small-for-gestational age, stillbirth, neonatal death, congenital anomalies, and neonatal intensive care admission) between women who conceived using clomiphene and those who conceived without clomiphene therapy. (This objective will be achieved by a linkage between PharmaNet and BC Perinatal database and Vital Statistics.)

Hypotheses:

1) Women who used clomiphene citrate prior to conception have a 20% higher risk of multiple births compared with women who did not use clomiphene.

2) Women who used clomiphene prior to conception have more than a 20% higher risk of adverse perinatal outcomes compared with women who did not use clomiphene.

Publications: 

Journal Publication

  • Lisonkova S,  Joseph KS. Temporal trends in clomiphene citrate use: a population-based study. Fertility Sterility 2012; 97(3):639-44

Academic thesis or dissertation

  • Lisonkova, S. "Impact of delayed childbearing in BC, Canada." University of British Columbia (2009) PhD Thesis

Page last revised: December 5, 2017