Mechanism of Aging Following Exposure to HIV Antiretroviral Drugs CIHR Team in HIV Therapy & Aging, CARMA-4 Part B:

Project number: 
14-077
Approval date: 
Tuesday, September 16, 2014
Principal Investigator: 
Janssen,Patricia
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Canadian Institutes of Health Research(CIHR)
Datasets requested: 
Births (BC Vital Statistics Agency)
Medical Services Plan (BC Ministry of Health)
Consolidation - demographic (Ministry of Health)
Deaths (BC Vital Statistics Agency)
Hospital Separations (BC Ministry of Health)
Consolidation registry (Ministry of Health)
Perinatal Services BC
bc cancer
consolidation - census geocodes
Research objective: 

1.To describe the incidence and nature of significant poor health outcomes such as infections defined by ICD9 and ICD10 codes, frequency and duration of hospital admissions, as well as impaired development of infants, children and youth born to HIV infected mothers stratified by:
- complexity/type of antiretroviral drug regimen
- length of perinatal exposure to antiretroviral therapy

2.To compare these health outcomes in HEU children to age, sex and geocode (first three letters of postal code) matched controls from the population database platform.

Hypothesis

Compared to a 3:1 age, sex and geocode matched cohort of British Columbian children, HIV-uninfected, ARV exposed children will have a higher frequency of poor health outcomes with higher incidence of infection as defined by ICD9 and ICD10 codes, frequency and duration of hospital admissions, and significant developmental disorders.

Publications: 

Presentation of research material (poster/seminar/lecture etc.)

  • Piske M, Budd M, Qiu A, Maan E, Sauve L, Alimenti A, Forbes J, Janssen P, Cote H, CIHR team grant on Cellular Aging and HIV Comorbidities in Women and Children (CARMA). A BC provincial database analysis of long-term developmental outcomes in HIV-exposed uninfected (HEU) children born to mothers living with HIV. Canadian association for HIV research (CAHR). April 7, 2017. Montreal QC Canada. (ORAL)

Page last revised: December 5, 2017