Cardiac Troponins and Sex Differences in Outcomes

Project number: 
14-020
Approval date: 
Tuesday, June 3, 2014
Principal Investigator: 
Humphries,Karin
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Canadian Institutes of Health Research(CIHR)
Datasets requested: 
Medical Services Plan (BC Ministry of Health)
Hospital Separations (BC Ministry of Health)
PharmaNet
Deaths (BC Vital Statistics Agency)
Consolidation registry (Ministry of Health)
Research objective: 

Research Question:

Does sex modify the relationship between troponin level and treatments/outcomes following emergency department (ED) admission for chest pain suggestive of ischemic coronary disease?

This study will examine whether sex modifies the relationship between troponin levels and outcomes including: a) the composite of all-cause mortality and rehospitalization for cardiac causes, collectively known as major adverse cardiac events (MACE); and b) the risk reduction strategies prescribed, specifically the use of statins, beta blockers, angiotensin converting enzyme (ACE)-inhibitors or angiotensin receptor blockers (ARB).

Hypothesis:

Women admitted with chest pain suggestive of ischemic coronary disease will have lower levels of troponin resulting in under diagnoses of acute myocardial infarction, less aggressive risk reduction, and worse outcomes compared to men.


Page last revised: December 5, 2017