Assessing tobacco-related cancers among individuals with psychiatric or drug use disorders in British Columbia

Project number: 
15-129
Approval date: 
Monday, December 7, 2015
Principal Investigator: 
Olson,Robert
Institution: 
BC Cancer
Funding Agency: 
BC Cancer
Datasets requested: 
PharmaCare (BC Ministry of Health)
Consolidation registry (Ministry of Health)
Deaths (BC Vital Statistics Agency)
Medical Services Plan (BC Ministry of Health)
PharmaNet
bc cancer-external
Hospital Separations (BC Ministry of Health)
Consolidation - demographic (Ministry of Health)
Research objective: 

Research Questions and Hypotheses:

a) Do individuals with psychiatric and drug-use disorders in British Columbia have an increased hazard of developing a tobacco-related cancer than individuals without psychiatric and drug-use disorders?
Hypotheses:
It is expected that the psychiatric and the drug cohorts will have a significantly greater hazard of developing a tobacco-related cancer than a population-proxy control (appendicitis).
It is expected that the mixed psychiatric-drug cohorts will have a significantly greater hazard of developing a tobacco-related cancer than a population-proxy control (appendicitis).

b) Do individuals with psychiatric and drug-use disorders in British Columbia have a shorter survival time from first cancer diagnosis until death than individuals without psychiatric and drug-use disorders?
Hypotheses:
It is expected that the psychiatric and the drug cohorts will have a significantly shorter survival time from first cancer diagnosis until death (using a Cox regression model to estimate survival time).
It is expected that the mixed psychiatric-drug cohorts will have a significantly shorter survival time from first cancer diagnosis until death.

c) Do individuals with psychiatric and drug-use disorders in British Columbia have a longer time from first diagnosis until appropriate cancer treatment than those without psychiatric and drug-use disorders?
Hypotheses:
It is expected that the psychiatric and the drug cohorts will have a significantly longer time from first diagnosis until appropriate cancer treatment.
It is expected that the mixed psychiatric-drug cohorts will have a significantly longer time from first diagnosis until appropriate cancer treatment.

d) Are individuals with psychiatric and drug-use disorders in British Columbia as likely to receive definitive treatment, including increased administration of palliative rather than curative doses of radiotherapy and decreased administration of chemotherapy, as individuals without psychiatric and drug-use disorders?
Hypotheses:
It is expected that the psychiatric and the drug cohorts will be significantly less likely to receive definitive treatment, including increased administration of palliative rather than curative doses of radiotherapy and decreased administration of chemotherapy.
It is expected that the mixed psychiatric-drug cohorts will be significantly less likely to receive definitive treatment, including increased administration of palliative rather than curative doses of radiotherapy and decreased administration of chemotherapy.

e) Do individuals with psychiatric and drug-use disorders have the same rate of completion of recommended treatment as those without psychiatric and drug-use disorders?
Hypotheses:
It is expected that the psychiatric and the drug cohorts will have significantly decreased rates of completion of recommended treatment.
It is expected that the mixed psychiatric-drug cohorts will have significantly decreased rates of completion of recommended treatment.

f) Do individuals with psychiatric and drug-use disorders living in rural areas in British Columbia have a shorter survival time from first cancer diagnosis until death than those living in urban areas?
Hypothesis:
It is expected that individuals with psychiatric and drug-use disorders living in rural areas will have a significantly shorter survival time from first cancer diagnosis until death than those living in urban areas.

g) Do individuals with psychiatric and drug-use disorders living in rural areas in British Columbia have a longer time from first diagnosis until appropriate cancer treatment than those living in urban areas?
Hypothesis:
It is expected that individuals with psychiatric and drug-use disorders living in rural areas will have significantly longer time from first diagnosis until appropriate cancer treatment than those living in urban areas.

h) Are individuals with psychiatric and drug-use disorders living in rural areas in British Columbia as likely to receive definitive treatment, including increased administration of palliative rather than curative doses of radiotherapy and decreased administration of chemotherapy, as individuals living in urban areas?
Hypothesis:
It is expected that individuals with psychiatric and drug-use disorders living in rural areas will be significantly less likely to receive definitive treatment, including increased administration of palliative rather than curative doses of radiotherapy and decreased administration of chemotherapy, than individuals living in urban areas.

i) Do individuals with psychiatric and drug-use disorders in British Columbia have an increased hazard of developing a non-malignant tobacco-related disease than individuals without psychiatric and drug-use disorders?
Hypothesis:
It is expected that the psychiatric and the drug cohorts will have a significantly greater hazard of developing a non-malignant tobacco-related disease than a population-proxy control (appendicitis).

j) Do individuals with psychiatric and drug-use disorders in British Columbia have a shorter survival time from first non-malignant tobacco-related disease diagnosis until death than individuals without psychiatric and drug-use disorders?
Hypothesis:
It is expected that the psychiatric and the drug cohorts will have a significantly shorter survival time from first tobacco-related disease diagnosis until death (using a Cox regression model to estimate survival time).


Page last revised: December 5, 2017