Dose-response of cranberry in women with recurrent Urinary Tract Infections

Project number: 
16-001
Approval date: 
Thursday, January 21, 2016
Principal Investigator: 
Stothers,Lynn
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Not Available
Datasets requested: 
Medical Services Plan (BC Ministry of Health)
PharmaCare (BC Ministry of Health)
Research objective: 

This prospective, randomized, placebo-controlled dose-response study aims to compare low dose and medium dose
cranberry juice to placebo in the prevention of recurrent urinary tract infections in adult women.

We hypothesize that:
1. The mean number of urinary tract infections will be significantly lower in subjects receiving cranberry juice compared with the group that receives placebo.
2. A dose response curve relating the number of infections in each group compared to their intake of cranberry can be constructed.
3. There is decreased utilization of outpatient physician visits for urinary tract infections in subjects receiving cranberry juice compared with placebo.
4. There is decreased utilization and cost of prescription drugs for urinary tract infections in patients using cranberry juice.

The specific aims are:
1. to further understand the clinical link between cranberry consumption and prevention of UTI.
2. to further understand the mechanistic link between cranberry consumption and prevention of urinary tract infections by determining urinary proanthocyanidin levels and its effect on E.Coli strains.
3. to determine the impact of cranberry juice doses on health care utilization by measuring the number of visits for inpatient services, outpatient, services, family practice and specialist services for urinary infection in each treatment group and measuring the number and type of prescription drugs used in the year prior to and after cranberry consumption based on dose exposure.


Page last revised: December 5, 2017