Long-term clinical and financial impact of asthma control during pregnancy and preschool years on disease evolution until adulthood.

Project number: 
16-169
Approval date: 
Friday, September 30, 2016
Principal Investigator: 
Sadatsafavi,Mohsen
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Not Available
Datasets requested: 
Consolidation - demographic (Ministry of Health)
Medical Services Plan (BC Ministry of Health)
Perinatal Services BC
consolidation - census geocodes
Hospital Separations (BC Ministry of Health)
PharmaNet
Deaths (BC Vital Statistics Agency)
Consolidation registry (Ministry of Health)
Research objective: 

Objectives:

Project 2. To evaluate the long-term impact of asthma control and use of controller medication in preschoolers with a new diagnosis of asthma.

Project 3. To compare the asthma evolution of offspring of pregnant mothers with asthma who are poorly vs. adequately controlled during pregnancy.

Hypotheses:

For the project 2, "Long-term impact of asthma control and use of controller medication in preschoolers with a new diagnosis of asthma", we will explore:

1.In children diagnosed with asthma in the first 5 years of life, we wish to describe during the 2 years following asthma diagnosis the: (i) the level of asthma control; (ii) level of asthma severity prior to initiation of controller therapy; (iii) time to initiation of first controller medication; (iv) choice of controller medication between 1990-2013 and the intra-individual therapy change over time; (v) pattern of medical prescriptions received in pharmacies (whether claimed or not); (vi) pattern, adherence, persistence,and overall use of asthma controller by patients (derived from drug claims).

2. We also wish to explore: (vii) whether asthma control in the 2 years following initial diagnosis predicts long-term outcome, and (viii) whether the delay until the initiation of controller therapy, patterns, persistence and overall use of controller medications modify long-term outcomes.

For the project 3, "Disease evolution of offspring of pregnant mothers with asthma who are poorly vs. adequately controlled during pregnancy", we will explore:

1. What is the long-term impact of poor maternal asthma control during pregnancy on the offsprings asthma control, disease evolution, acute health care resources utilization and health care cost?


Page last revised: December 5, 2017