Long-term clinical and financial impact of asthma control during pregnancy and preschool years on disease evolution until adulthood.
Project 2. To evaluate the long-term impact of asthma control and use of controller medication in preschoolers with a new diagnosis of asthma.
Project 3. To compare the asthma evolution of offspring of pregnant mothers with asthma who are poorly vs. adequately controlled during pregnancy.
For the project 2, "Long-term impact of asthma control and use of controller medication in preschoolers with a new diagnosis of asthma", we will explore:
1.In children diagnosed with asthma in the first 5 years of life, we wish to describe during the 2 years following asthma diagnosis the: (i) the level of asthma control; (ii) level of asthma severity prior to initiation of controller therapy; (iii) time to initiation of first controller medication; (iv) choice of controller medication between 1990-2013 and the intra-individual therapy change over time; (v) pattern of medical prescriptions received in pharmacies (whether claimed or not); (vi) pattern, adherence, persistence,and overall use of asthma controller by patients (derived from drug claims).
2. We also wish to explore: (vii) whether asthma control in the 2 years following initial diagnosis predicts long-term outcome, and (viii) whether the delay until the initiation of controller therapy, patterns, persistence and overall use of controller medications modify long-term outcomes.
For the project 3, "Disease evolution of offspring of pregnant mothers with asthma who are poorly vs. adequately controlled during pregnancy", we will explore:
1. What is the long-term impact of poor maternal asthma control during pregnancy on the offsprings asthma control, disease evolution, acute health care resources utilization and health care cost?