Contemporary Treatment and Outcomes of Atrial Fibrillation

Project number: 
Approval date: 
Wednesday, August 29, 2018
Principal Investigator: 
St. Pauls Hospital
Funding Agency: 
Heart and Stroke Foundation of Canada,UBC Cardiology
Datasets requested: 
Consolidation - demographic (Ministry of Health)
consolidation - census geocodes
Hospital Separations (BC Ministry of Health)
Deaths (BC Vital Statistics Agency)
Medical Services Plan (BC Ministry of Health)
Consolidation registry (Ministry of Health)
Research objective: 

Aim 1 Define the burden of AF, clinical outcomes and associated healthcare utilization.
1. Contemporary state and temporal changes in incidence and prevalence of AF, characteristics of patients with AF, and their rates of mortality, stroke and bleeding outcomes.
2. Healthcare utilization: hospitalizations, ED and office visits, investigations and procedures.
3. Population and health service demand modelling.

Aim 2 Assess anticoagulation treatment patterns and develop a tool to predict net clinic benefit.
1. Treatment patterns (uptake, switching, adherence, dosing) between anticoagulants and prescribers.
2. Anticoagulation uptake and outcomes in relation to stroke and bleeding risk.
3. Methods of predicting net benefit of anticoagulation in newly diagnosed AF.

Aim 3 Assess high risk groups and inequalities.
1. Management of high risk groups, in particular concomitant HF, COPD, and CKD.
2. Inequalities in healthcare utilization and anticoagulation use according to age, sex, ethnicity, patient residence (rural vs. urban), and healthcare setting of initial AF diagnosis.

Page last revised: December 5, 2018