Annual Direct Burden of Illness for Heart Failure in British Columbia, Canada: Administrative Database Analysis of Ambulatory and Inpatient Care

Project number: 
17-071
Approval date: 
Thursday, June 1, 2017
Principal Investigator: 
Levy,Adrian
Institution: 
Dalhousie University
Funding Agency: 
Not Available
Datasets requested: 
Not available
Research objective: 

The objective of this study is to estimate the annual direct burden of illness of HF in British Columbia between 2009 and 2014, as part of a larger pan-Canadian strategy to characterize provincial data and estimate national trends. This objective will be achieved through an analysis of prevalence, resource utilization, and direct medical costs using population-based administrative health data from British Columbia.

Detailed study Objectives:

1 Determine the annual sex- and age-specific and total prevalence of HF during the study period
2 Characterize treatment patterns by the number and percent receiving medication classes and treatment modalities of medication of interest, over the entire study period, and by calendar year
3 Characterize resource utilization and direct costs according to inpatient, outpatient, and pharmaceutical use among individuals with non-zero resource use
4 Estimate hospitalization length of stay and costs associated with intensive care unit stay vs. general ward
5 Determine time trends in hospitalization costs by calendar year
6 Determine time trends in the ratio of inpatient to outpatient costs by calendar year
7 To estimate the mortality rate among HF patients in ICU
8 Determine mortality rate in the prevalent HF population
9 To characterize the comorbidity burden using the 31-item Elixhauser comorbidity score
10 To identify primary and secondary diagnoses of HF at an individual level
11 To evaluate the sensitivity of the results on classification of reduced ejection fraction HF, when using 4- and 5- digit ICD codes

1) Key research questions include:

a. What is the overall direct medical cost for HF in British Columbia?
b. What is the cost associated with hospitalization for HF in British Columbia?
c. What is the distribution between intensive care vs. general ward costs, the ratio of hospitalization to outpatient costs, and temporal trends in these outcomes?

2) Hypotheses: This study is descriptive in nature and no comparative hypotheses will be tested.


Page last revised: May 13, 2019