Examining the epidemiology, treatment, and survival in young-onset colorectal cancer (EXPLAIN-yCRC)

Project number: 
18-088
Approval date: 
Wednesday, October 10, 2018
Principal Investigator: 
De Vera,Mary
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Canadian Institutes of Health Research(CIHR)
Datasets requested: 
Hospital Separations (BC Ministry of Health)
Consolidation - demographic (Ministry of Health)
Consolidation registry (Ministry of Health)
Deaths (BC Vital Statistics Agency)
Citizenship and Immigration Canada (CIC) Permanent Residents
consolidation - census geocodes
Medical Services Plan (BC Ministry of Health)
Research objective: 

We propose to combine our expertise in epidemiology, health services research, health economics, and cancer research to data rich resources in British Columbia to explain and inform the contemporary epidemiology, treatment, and outcomes, including survival and mortality, and healthcare utilization, and costs in yCRC, as compared to those with CRC. Using linked provincial health databases including a population-based cancer registry, our research questions and corresponding objectives (and where relevant, hypotheses), to be undertaken for individuals with yCRC and, in comparison, those with CRC are:

To address the first research question on whether the risk and burden of yCRC is increasing, our first objective is to assess temporal trends in the epidemiology of yCRC (as compared to CRC) to address the hypotheses that the risk and burden of yCRC is increasing.

To address the second research question on how is yCRC being treated, our second objective is to delineate and compare patterns of treatment in yCRC and CRC to address the hypotheses that patient, contextual, and system factors influence treatment patterns in yCRC.

To address the third research question on what are the outcomes of patients with yCRC, our third objective is to evaluate patient outcomes in individuals with yCRC compared to those with CRC.


Page last revised: May 13, 2019