Evaluating the association between inhaled corticosteroid and statin use and the development of lung cancer in COPD patients: a linked health database study

Project number: 
08-015
Approval date: 
Monday, March 1, 2010
Principal Investigator: 
Lynd,Larry
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Canadian Institutes of Health Research(CIHR)
Datasets requested: 
Medical Services Plan (BC Ministry of Health)
Hospital Separations (BC Ministry of Health)
Consolidation file (BC Ministry of Health)
Deaths (BC Vital Statistics Agency)
consolidation - census geocodes
bc cancer
Research objective: 

Among patients with chronic obstructive pulmonary diesease (COPD) the most common cause of death is lung cancer. Data suggest lung cancer may be influenced by the use of inhaled corticosteroids (ICS) and HMG-CoA reductase inhibitors (statins), respectively; animal models have shown that lung tumor formation may be inhibited by the administration of ICS and epidemiologic data have shown decreased incidence of cancer associated with the use of statins. The objectives of our proposed research are therefore to: a) determine the association between the use of ICS and/or statins and the development of lung cancer in a retrospective cohort study using administrative healthcare data; b) explore differences within a cohort of male and female COPD patients by identifying patients who also meet more restrictive COPD case definitions; c) determine the frequency of use of ICS and/or statins in the COPD population; d) determine if there are differential effects of ICS and/or statins on specific types of lung cancer; and f) examine if there is a differential effect across gender.

Publications: 

Journal Publication

  • Inhaled corticosteroids and the risk of lung cancer in chronic obstructive pulmonary disease (COPD): a population-based cohort study
    A.J.N. Raymakers, M. Sadatsafavi, D.D. Sin, J.M. FitzGerald, C.A. Marra, L.D. Lynd
    European Respiratory Journal Jan 2019, 1801257; DOI: 10.1183/13993003.01257-2018

Presentation of research material (poster/seminar/lecture etc.)

  • Rayamkers AJN, Sadatsafavi M, Lynd LD. One-year survival among statin users in a population-based cohort of COPD patients. Canadian Association for Population Therapeutics (CAPT). Toronto, Ontario (2015, 2 November). (Poster Presentation)
  • Raymakers AJN, Marra CA, Sadatsafavi M, FitzGerald JM, Sin DD, Lynd LD. A
    population-based cohort study evaluating the association between inhaled
    corticosteroid use and lung cancer development in patients with COPD.
    Canadian Institutes of Health Research, Institute of Circulatory and
    Respiratory Health Young Investigators Forum. Edmonton, Alberta (2014, 26
    May). (Poster presentation)
  • Raymakers AJN, Marra CA, Sadatsafavi M, FitzGerald JM, Sin DD , Lynd LD. Inhaled corticosteroid (ICS) use in Chronic Obstructive Pulmonary Disease and Lung Cancer diagnosis. Institute for Heart and Lung Health FEST 2014. Vancouver, British Columbia (2014, 7 February). (Poster presentation)
  • Raymakers AJN, Marra CA, FitzGerald JM, Sadatsafavi M, Sin DD, Lynd LD" A population-based cohort study evaluating the association between inhaled corticosteroid use and lung cancer development in patients with COPD" Canadian Institutes of Health Research, Institute of Circulatory and Respiratory Health. Toronto, Ontario (27 May).

Conference abstract/presentation

  • aymakers AJN, Sadatsafavi M, Sin DD, Fitzgerald JM, Marra C,Lynd LD An evaluation of the association between statin use and lung cancer risk in chronic obstructive pulmonary disease patients. Poster presentation.
    Canadian Centre for Applied Research in Cancer Control Conference, May 25 2017

Page last revised: September 2, 2019