Antidepressants and risk of suicide or self-harm in Canadian youth: a national population-based study
Antidepressant-related self-harm in youth has generated great concern among regulatory authorities. To assess the association between antidepressant use and self-harm we propose to: 1) Estimate the incidence rate of non-fatal self-harm among youth aged 10-19 in BC who are taking antidepressants; 2) compare classes of antidepressants with respect to the rate of non-fatal self-harm; 3) ascertain the incidence rate of non-fatal self-harm as a function of treatment duration and following discontinuation, i.e., the hazard function; 4) determine the hazard ration (i.e., adherence, psychiatric diagnosis, comedication, socio-economic status, previous self-harm episodes) in order to identify high-risk patients; and 6) determine whether there is an association between anti-depressant use and suicide using BC Coroner's Service reports to identify suicides.
Conference abstract/presentation
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1. International Society for of Pharmacoepidemiology (ISPE) 2014 - Abstracts of the 30th International Conference on Pharmacoepidemiology and Therapeutic Risk Management (ICPE), October 24–27, 2014, Taipei, Taiwan
Conference abstract published in:
Larry L Lynd, Thierry Ducruet, Kathy Li, Marie Tournier, Brian Greenfield, Yola Moride. Antidepressants and risk of suicide or self-harm in Canadian
youth: A study involving common data models in Quebec and British Columbia.
In: Pharmacoepidemiol Drug g Saf. 2014;23(S1). doi: 10.1002/pds.3701.2. French Congress of Psychiatry (Congrès Français de Psychiatrie 2015), Lille, France, November 25-28, 2015
Conference abstract published in:
Y. Moride , L. Lynd, H. Ducruet , H. Li , M. Tournier , B. Greenield.
Antidepressants and risk of suicide or self-harm in Canadian youth: A study involving common data models in Quebec and British Columbia. In: Congrès franc¸ ais de psychiatrie / European Psychiatry 30S (2015) S9–S65: SC1.
doi: 10.1016/j.europsy.2015.09.038.