The Epidemiology and Impact of Comorbidity on MS in Canada (ECoMS) - Characterization of Comorbidities in MS

Project number: 
10-007
Approval date: 
Friday, March 9, 2012
Principal Investigator: 
Tremlett,Helen
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Canadian Institutes of Health Research(CIHR)
Datasets requested: 
PharmaNet
Hospital Separations (BC Ministry of Health)
Consolidation - demographic (Ministry of Health)
Vancouver Coastal Health Authority
Deaths (BC Vital Statistics Agency)
Consolidation registry (Ministry of Health)
MSP Registration & Premium Billing(BC Ministry of Health)
consolidation - census geocodes
Medical Services Plan (BC Ministry of Health)
Researcher collected
Research objective: 

The aim of this project is to identify comorbidities among patients with MS, how these vary across sociodemographic groups, and differ from comorbidities in the general population.

-to identify comorbidities among patients with MS occurring with a frequency >=5%
-to determine which comorbidities occur with different frequencies than in the general population
-to determine temporal trends in MS-related comorbidities
-to describe the burden of illness related to MS in British Columbia; specifically, to estimate annual incidence and prevalence and trends in MS among British Columbia residents with stratification by age, sex, and geographic region of residence.
-to determine how comorbidity affects health-related quality of life (HRQoL) in MS
-to determine how psychiatric symptoms which do not meet formal diagnostic criteria affect HRQoL in MS

Publications: 

Journal Publication

  • Kingwell, Elaine, et al. “Socioeconomic status and disability progression in multiple sclerosis: a multi-national study” Neurology. 2019.
  • Marrie RA, Patten SB, Berrigan LI, Tremlett H, Wolfson C, Warren S, Leung S, Fiest KM, McKay KA, Fisk JD. Diagnoses of Depression and Anxiety Versus Current Symptoms and Quality of Life in Multiple Sclerosis. International journal of MS care. 2018 Mar;20(2):76-84.
  • McKay, et al. “Psychiatric comorbidity is associated with disability progression in multiple sclerosis” Neugology 2018.
  • McKay, et al. “Comorbidities are associated with altered health service use in multiple sclerosis: a prospective cohort study” Neuroepidemiology 2018.
  • Marrie, R.A. et al. "Differing trends in the incidence of vascular comorbidity in MS and the general population." Neurology: Clinical Practice 6.2 (2016): 120-128.
  • McKay, K.A., et al (2017)."Disease-Modifying Therapies and Adherence in Multiple Sclerosis: Comparing Patient Self-Report with Pharmacy Records." Neuroepidemiology 2017 Jul 7;48(3-4):124-130
  • Zhang T, Tremlett H, Tennakoon A, Leung S, Zhu F, Kingwell et al. Examining the effects of comorbidities on disease-modifying therapy use in multiple sclerosis. Neurology. 2016;86:1-9.
  • Marrie, Ruth Ann, et al. "Chronic lung disease and multiple sclerosis: Incidence, prevalence, and temporal trends." Multiple Sclerosis and Related Disorders 8 (2016): 86-92.
  • E. Kingwell, F. Zhu, R.A. Marrie, J.D. Fisk, C. Wolfson, S. Warren, J. Profetto-McGrath, L.W. Svenson, N. Jette, V. Bhan, B.N. Yu, L. Elliott, H. Tremlett. High incidence and increasing prevalence of multiple sclerosis in British Columbia, Canada: findings from over two decades (1991-2010). J Neurol. 2015 DOI: 0.1007/s00415-015-7842-0
  • Kingwell, Elaine, et al. "High incidence and increasing prevalence of multiple sclerosis in British Columbia, Canada: findings from over two decades (1991–2010)." Journal of neurology 262.10 (2015): 2352-2363.
  • Marrie, Ruth Ann, et al. "Differences in the burden of psychiatric comorbidity in MS vs the general population." Neurology 85.22 (2015): 1972-1979.

Presentation of research material (poster/seminar/lecture etc.)

  • Kingwell, Elaine, et al. “Socioeconomic status and progression of disability in MS” Presentation of research material (poster/seminar/lecture etc.). 2018. Presented as a poster at the Association of British Neurologists annual meeting in Birmingham, UK.

Conference abstract/presentation

  • Kingwell, Elaine, et al. “Socioeconomic status and progression of disability in MS” Submitted for the Association of British Neurologists annual conference, May 2018 - Birmingham (United Kingdom)
  • McKay KA, Tremlett H, Zhu F, Kastrukoff L, Marrie RA, & Kingwell E. (2016). A population based study comparing multiple sclerosis clinic users and non-users in British Columbia, Canada. European Journal of Neurology, 23(6), 1093-1100
  • Kingwell, Elaine, et al. “High incidence and increasing prevalence of multiple sclerosis in British Columbia, Canada: findings from over two decades (1991-2010).” 2014 Joint ACTRIMS-ECTRIMS Meeting, 10th-13th September in Boston.

Page last revised: September 2, 2019