EmPhAsIS: Empowering Pharmacists in Asthma management through Interactive SMS

Project number: 
18-119
Approval date: 
Thursday, March 28, 2019
Principal Investigator: 
De Vera,Mary
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Not Available
Datasets requested: 
Medical Services Plan (BC Ministry of Health)
Consolidation file (BC Ministry of Health)
PharmaNet
Consolidation - demographic (Ministry of Health)
NACRS
Hospital Separations (BC Ministry of Health)
consolidation - census geocodes
Research objective: 

RESEARCH QUESTIONS:
1. What is the effect of a pharmacist-initiated adherence intervention that involves patient education, monthly text messages to assess adherence to controller therapies, and pharmacist follow-up of non-adherent patients (EmPhAsIS intervention) on adherence (Objectives 1 and 2)?
2. What is the effect of a pharmacist-initiated adherence intervention that involves patient education, monthly text messages to assess adherence to controller therapies, and pharmacist follow-up of non-adherent patients (EmPhAsIS intervention) on patient outcomes (Objective 1a)?
3. Is a pharmacist-initiated adherence intervention that involves patient education, monthly text messages to assess adherence to controller therapies, and pharmacist follow-up of non-adherent patients (EmPhAsIS intervention) cost-effective (Objective 3)?

STUDY HYPOTHESES
Hypothesis 1: Compared to the usual care, the proposed intervention (EmPhAsIS intervention) improves one-year adherence to ICS in patients with asthma.
Hypothesis 2: The improvement in adherence is sustained over one year after the initiation of the intervention.
Hypothesis 3: The intervention (EmPhAsIS intervention) is cost-effective from a societal perspective, considering the long-term outcomes associated with better adherence to ICS in asthma.

OBJECTIVES
Objective 1: To compare adherence to ICS, measured objectively and defined as the medication possession ratio (MPR), adjusted for potentially confounding variables, between the intervention (receiving the EmPhAsIS intervention) and the control (receiving usual care) groups.
Objective 1a: To compare patient outcomes between intervention (receiving the EmPhAsIS intervention) and the control (receiving usual care) groups.
Objective 2: To compare the trend over time of the adherence to ICS in the intervention (receiving the EmPhAsIS intervention) compared with the control groups (receiving usual care) .
Objective 3: To calculate the incremental cost-effectiveness ratio (ICER) of the proposed intervention (EmPhAsIS intervention) vs. that of usual care, at the population level and across subgroups, from the societal perspective over a ten-year time horizon.


Page last revised: September 2, 2019