Mechanism of Aging Following Exposure to HIV Antiretroviral Drugs CIHR Team in HIV Therapy & Aging, CARMA-4 Part B:

Project number: 
14-077
Approval date: 
Tuesday, September 16, 2014
Principal Investigator: 
Janssen,Patricia
Institution: 
University of British Columbia (UBC)
Funding Agency: 
Canadian Institutes of Health Research(CIHR)
Datasets requested: 
Perinatal Services BC
bc cancer
consolidation - census geocodes
Births (BC Vital Statistics Agency)
Medical Services Plan (BC Ministry of Health)
Consolidation - demographic (Ministry of Health)
Deaths (BC Vital Statistics Agency)
Hospital Separations (BC Ministry of Health)
Consolidation registry (Ministry of Health)
Research objective: 

1.To describe the incidence and nature of significant poor health outcomes such as infections defined by ICD9 and ICD10 codes, frequency and duration of hospital admissions, as well as impaired development of infants, children and youth born to HIV infected mothers stratified by:
- complexity/type of antiretroviral drug regimen
- length of perinatal exposure to antiretroviral therapy

2.To compare these health outcomes in HEU children to age, sex and geocode (first three letters of postal code) matched controls from the population database platform.

Hypothesis

Compared to a 3:1 age, sex and geocode matched cohort of British Columbian children, HIV-uninfected, ARV exposed children will have a higher frequency of poor health outcomes with higher incidence of infection as defined by ICD9 and ICD10 codes, frequency and duration of hospital admissions, and significant developmental disorders.

Publications: 

Journal Publication

  • Exploring the live birth rates of women living with HIV in British Columbia, Canada. Van Ommen CE, Albert AYK, Piske M, Money DM, Cote HCF, Lima VD, Maan EJ, Alimenti A, van Schalkwyk J, Pick N, Murray MCM. PLoS One. 2019 Feb 6;14(2):e0211434. doi: 10.1371/journal.pone.0211434. eCollection 2019.
  • Neurodevelopmental outcomes and in-utero antiretroviral exposure in HIV-exposed uninfected children. Piske M, Budd MA, Qiu AQ, Maan EJ, Sauve LJ, Forbes JC, Alimenti A, Janssen P, Cote HCF; CIHR Team Grant on Cellular Aging and HIV Comorbidities in Women and Children (CARMA). AIDS. 2018 Nov 13;32(17):2583-2592. doi: 10.1097/QAD.0000000000001985.

Presentation of research material (poster/seminar/lecture etc.)

  • Micah Piske, Matthew A. Budd, Annie Q. Qiu, Evelyn J. Maan, Laura J. Sauve, Ariane Alimenti, John C. Forbes, Patricia Janssen, Helene C.F. Cote, and the CIHR Team on Cellular Aging and HIV Comorbidities in Women and Children (CARMA). Developmental outcomes and ARV exposure in HIV-exposed uninfected children. Poster presentation at the Conference for Retroviruses and Opportunistic Infections (CROI), Boston, MA, USA. April 4-7, 2018.
  • Micah Piske, Matthew A. Budd, Annie Q. Qiu, Evelyn J. Maan, Laura J. Sauve, Ariane Alimenti, John C. Forbes,, Patricia Janssen, Helene C.F. Cote.Mitochondrial DNA and Neurodevelopmental disorders in HEU children. Brief presentation given at the HEU Child workshop in Paris, France. July 28, 2017.
  • Micah Piske, Matthew A. Budd, Annie Q. Qiu, Evelyn J. Maan, Laura J. Sauve, Ariane Alimenti, John C. Forbes, Patricia Janssen, Hélène C.F. Côté, and the CIHR Team on Cellular Aging and HIV Comorbidities in Women and Children (CARMA). A BC Provincial Database Analysis of Long Term Developmental Outcomes in HIV-Exposed Uninfected (HEU) Children Born to Mothers Living with HIV. Oral presentation at the Canadian Association for HIV Research, Montreal, Canada. April 6-9, 2017.

Conference abstract/presentation

  • Micah Piske, Matthew A. Budd, Annie Q. Qiu, Evelyn J. Maan, Laura J. Sauve, Ariane Alimenti, John C. Forbes, Patricia Janssen, Hélène C.F. Côté, and the CIHR Team on Cellular Aging and HIV Comorbidities in Women and Children (CARMA). Long-term developmental outcomes and in utero antiretroviral exposure in HIV-exposed uninfected (HEU) children born to women living with HIV in British Columbia (BC), Canada. Poster presentation at the International AIDS Society (IAS) Conference on HIV Science, Paris, France. July 21-22, 2017.

Page last revised: January 21, 2020