Pregnancy Complications and the Risk of Future Cardiovascular Disease

Project number: 
19-005
Approval date: 
Friday, November 22, 2019
Principal Investigator: 
Grandi,Sonia
Institution: 
McGill University
Funding Agency: 
Canadian Institutes of Health Research(CIHR)
Datasets requested: 
Stillbirths (BC Vital Statistics Agency)
Medical Services Plan (BC Ministry of Health)
Perinatal Services BC
PharmaNet
Deaths (BC Vital Statistics Agency)
Hospital Separations (BC Ministry of Health)
Research objective: 

Primary Objective: To develop a risk prediction model that estimates the 5-year risk of incident CVD among recently post-partum women, accounting for obstetrical history and complications of pregnancy.

Secondary Objectives:
a. To examine the potential mediating roles of predictors in order to inform the inclusion of interaction terms in our prediction models.
b. To develop a simplified risk prediction model that estimates the 5-year risk of incident CVD
among recently post-partum women.
c. To externally validate the risk prediction models developed in objectives 1 and 2a.
d. To determine the incremental value of predictors during pregnancy and delivery to:
i. The Framingham and QRISK2 models for prediction of subsequent CVD; and
ii. A predictive model that includes contemporary CVD predictors but not obstetrical
history and complications of pregnancy.


Page last revised: January 21, 2020