Mapping the epidemiology and the role of treatments in mental health complications in inflammatory arthritis (MATTERS)
We propose to apply our multidisciplinary expertise in health services research, rheumatology, and mental health to comprehensively study the epidemiology and roles of treatment in psychiatric complications in IA namely AS, gout, PsA, RA, and SARDs. Centered on the hypothesis that psychiatric complications, namely depression and anxiety, are substantial in IA our specific objectives, taking into account differences between women and men, are to:
Objective 1: Conduct epidemiologic studies to:
a) assess the burden (prevalence) of psychiatric complications in IA taking into consideration the prodromal period;
b) assess the risk (incidence) of psychiatric complications in IA;
c) evaluate the impact of psychiatric complications on mortality risk in IA.
Objective 2: Conduct pharmacoepidemiologic studies and identify the roles of treatment by:
a) delineating patterns of pharmacologic treatment for psychiatric complications in IA;
b) assessing psychological treatment for psychiatric complications in IA;
c) evaluating the association between specific treatments for IA (e.g., anti-tumour necrosis factor [TNF] therapy) and onset of psychiatric complications.