Echocardiographic Predictors of Long Term Outcomes in Patients with Severe Isolated Tricuspid Regurgitation

Project number: 
20-020
Approval date: 
Friday, February 21, 2020
Principal Investigator: 
David,Louis-Philippe
Institution: 
University of British Columbia (UBC)
Funding Agency: 
UBC Cardiology
Datasets requested: 
Medical Services Plan (BC Ministry of Health)
Consolidation file (BC Ministry of Health)
Deaths (BC Vital Statistics Agency)
Consolidation - demographic (Ministry of Health)
Researcher collected
Hospital Separations (BC Ministry of Health)
Research objective: 

a) RESEARCH QUESTIONS
Primary Objective:
1) Determine the baseline RV/RA echocardiographic predictors of adverse outcomes among patients with severe isolated TR.

Secondary Objectives:
1) Determine prevalence of isolated TR in a large population of patients with severe TR
2) Compare the rates of adverse cardiac events of patients with different etiologies of severe TR with patients with isolated TR. Potential subgroup of patients include:
a. Patients with pacemaker
b. Patients with likely pulmonary hypertension (Systolic pulmonary artery pressure >50 mmHg)
c. Patients with severe mitral regurgitation or severe aortic stenosis
d. Patients with congenital heart disease
e. Patients with left ventricular ejection fraction f. Patients with endocarditis
g. Patients with isolated tricuspid valve leaflet pathology (flail/prolapse)

b) HYPOTHESES
- Right ventricular markers of size and function will independently predict adverse cardiac outcomes among patients with severe isolated TR.
- Prognosis of severe isolated TR is better than other etiologies of severe TR


Page last revised: May 5, 2020