The population trend in fertility drug use and its impact on pregnancy outcomes
1) To compare the rates of multi-fetal births between women who conceived using clomiphene and those who conceived without such drug use (during the years 2000-2008.
2) To compare rates of adverse birth outcomes (including preterm birth, small-for-gestational age, stillbirth, neonatal death, congenital anomalies, and neonatal intensive care admission) between women who conceived using clomiphene and those who conceived without clomiphene therapy. (This objective will be achieved by a linkage between PharmaNet and BC Perinatal database and Vital Statistics.)
1) Women who used clomiphene citrate prior to conception have a 20% higher risk of multiple births compared with women who did not use clomiphene.
2) Women who used clomiphene prior to conception have more than a 20% higher risk of adverse perinatal outcomes compared with women who did not use clomiphene.
- Lisonkova S, Joseph KS.
Temporal trends in clomiphene citrate use: a population-based study.
Fertility Sterility 2012; 97(3):639-44