The Growing Burden of Cystic Fibrosis in British Columbia

Project number: 
19-104
Approval date: 
Friday, November 22, 2019
Principal Investigator: 
Desai,Sameer
Institution: 
UBC School of Population and Public Health
Funding Agency: 
Not Available
Datasets requested: 
Not available
Research objective: 

Research Questions (RQ):

RQ1. What is the temporal variation in important population health measures (frequency of CF diagnoses, mortality) as well as clinical measures (respiratory status, nutritional status, co-morbidities, microbiology, transplants) among individuals with CF?
Hypothesis: We hypothesize that the epidemiological burden and clinical burden should remain relatively stable in terms of incidence, with a likely spike recently due to more sensitive diagnostic testing. We expect prevalence to increase over time with better availability of medication in the last few decades.

RQ2. What is the geographical variation in important population health and clinical measures among individuals with CF?
Hypothesis: We hypothesize that those living furthest away from the clinic, especially in regards to co-morbidities will have worse outcomes

RQ3. What is the temporal variation in total and excess direct healthcare costs among individuals with CF?
Hypothesis: We hypothesize that the economic burden will increase over time, primarily due to expensive medication and more involved care in to late adulthood.

RQ4. What is the geographical variation in total and excess direct healthcare costs among individuals with CF?
Hypothesis: We hypothesize that the economic burden will increase over time, in patients living furthest away

RQ5: What are the longitudinal predictors of the total direct healthcare costs and high-cost (i.e., upper 25%) for individuals with CF?
Hypothesis: No hypothesis


Page last revised: July 14, 2020